I know remakes are going to be a thing forever, but what are your thoughts on games using the same region, but with an entirely different plot, and entirely new Pokemon. For example, before Let’s Go P/E was revealed, there were all these wild rumors about a Kanto Region in the future with all new Pokemon, Gorochu, submerged Pallet Town, a snake legendary, etc.
I dunno that I have “thoughts” on it, exactly. It’s a thing you could do. I mean, it’s a thing Black and White 2 did, and those games are pretty well regarded in the fan community, from what I’ve seen (there probably isn’t much merit in using an existing region and deliberately keeping no connections at all to the previous plot – if you’re not using the background, then the freedom of a new setting is probably more valuable). I don’t think it’s necessarily better or worse than setting a game in a completely new region; the latter gives you a blank slate for developing new ideas and themes, and the former emphasises continuity. I honestly do think there is a lot to be said for the blank slate, but sometimes having a pre-existing developed setting with dense lore and history can also be useful for storytelling – that’s why fan fiction is a thing. I probably wouldn’t do a whole new generation’s worth of Pokémon designs for a new game set in an existing region, though.